The male pill YCT-529 has passed its first human safety trial, a major breakthrough in reproductive health.
Developed by YourChoice Therapeutics, YCT-529 is a non-hormonal oral contraceptive that temporarily stops sperm production by blocking the retinoic acid receptor alpha (RAR-α).
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This receptor is key to vitamin A signaling for sperm development and by blocking it YCT-529 disrupts spermatogenesis without affecting testosterone or male hormones.
Unlike earlier male contraceptives that used hormones and caused side effects like mood swings, libido loss or weight gain, YCT-529 maintains hormonal balance.
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This hormone-free approach will be a game changer for men.
Preclinical trials in mice and monkeys showed 99% efficacy in preventing pregnancy with full and reversible fertility restoration within weeks of stopping the drug.
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Human Phase 1a trials with 16 healthy men showed the pill was well tolerated with no serious side effects or impact on libido and testosterone.
Now longer term Phase 1b/2a trials with more participants are underway to see how long YCT-529 suppresses sperm production and to monitor safety.
These trials are 28 and 90 days dosing and will confirm consistent efficacy and reversibility.
YCT-529 could be the first reliable, reversible, oral male pill, expanding family planning options beyond condoms and vasectomy.
It will promote shared contraceptive responsibility and reproductive autonomy, a major step towards gender equity in birth control.
YCT-529 is a revolutionary non-hormonal male pill that stops sperm production without hormonal side effects, with early human trial results and ongoing studies to confirm long term safety and efficacy